The art of clinical management in pharmacologic trials with depressed elderly patients -: Lessons from the Pittsburgh study of maintenance therapies in late-life depression

被引：22

作者：

Miller, MD ^{[1
]}

Frank, E ^{[1
]}

Reynolds, CF ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin,Dept Psychiat, Intervent Res Ctr Study Late Life Mood Disorders, Pittsburgh, PA 15213 USA

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 1999年 / 7卷 / 03期

关键词：

D O I：

10.1097/00019442-199908000-00007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The authors outline the clinical management methods use din a long-term study of depressed elderly patients and comment on the positive aspects of such interventions on the successful recruitment and retention of subjects. Psychological or clinical management (CM) is the "glue" that holds a successful drug trial together CM is recognized to be an essential element for success in drug trials for geriatric depression. The authors also discuss potentially negative aspects of comprehensive CM, such as those obscuring a psychotherapeutic effect in comparative studies.

引用

页码：228 / 234

页数：7

共 15 条

[1]

CARNEY RM, 1995, HEALTH PSYCHOL, V14, P88, DOI 10.1037/0278-6133.14.1.88

[2]

ELKIN I, 1989, ARCH GEN PSYCHIAT, V46, P971

[3]

FAWCETT J, 1987, PSYCHOPHARMACOL BULL, V23, P309

[4]

Frank E, 1997, J CLIN PSYCHIAT, V58, P11

[5]

JACOB M, 1987, HOSP COMMUNITY PSYCH, V38, P968

[6]

KARP JF, 1993, DEPRESSION, V1, P250

[7]

Klerman GL., 1984, INTERPERSONAL PSYCHO

[8]

Kunik Mark E, 1993, Am J Geriatr Psychiatry, V1, P38, DOI 10.1097/00019442-199300110-00006

[9]

Miller M D, 1991, J Geriatr Psychiatry Neurol, V4, P226, DOI 10.1177/089198879100400409

[10] Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression - A randomized controlled trial in patients older than 59 years [J].

Reynolds, CF ;

Frank, E ;

Perel, JM ;

Imber, SD ;

Cornes, C ;

Miller, MD ;

Mazumdar, S ;

Houck, PR ;

Dew, MA ;

Stack, JA ;

Pollock, BG ;

Kupfer, DJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (01) :39-45

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