Inflammation After Stroke: Mechanisms and Therapeutic Approaches

被引：75

作者：

Ahmad, Muzamil ^{[1
,2
]}

Graham, Steven H. ^{[1
,2
]}

机构：

[1] VA Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr 00 GR H, Pittsburgh, PA 15206 USA

[2] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

来源：

TRANSLATIONAL STROKE RESEARCH | 2010年 / 1卷 / 02期

关键词：

Stroke; Ischemia; Inflammation; Inflammatory cells; Cytokines; Cell adhesion molecules; Eicosanoids; INTERCELLULAR-ADHESION MOLECULE-1; CEREBRAL-ARTERY OCCLUSION; NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ACUTE ISCHEMIC-STROKE; INTERLEUKIN-1 RECEPTOR ANTAGONIST; NEUTROPHIL INHIBITORY FACTOR; ENDOTHELIAL-CELL ACTIVATION; MESSENGER-RNA EXPRESSION; PGE(2) EP2 RECEPTOR;

D O I：

10.1007/s12975-010-0023-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Reperfusion of ischemic brain can reduce injury and improve outcome, but secondary injury due to inflammatory mechanisms limits the efficacy and time window of such treatments for stroke. This review summarizes the cellular and molecular basis of inflammation in ischemic injury as well as possible therapeutic strategies.

引用

页码：74 / 84

页数：11

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