α-glucosidase inhibitors from Commelina communis

被引：110

作者：

Kim, HS ^{[1
]}

Kim, YH ^{[1
]}

Hong, YS ^{[1
]}

Paek, NS ^{[1
]}

Lee, HS ^{[1
]}

Kim, TH ^{[1
]}

Kim, KW ^{[1
]}

Lee, JJ ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Nat Prod Biosynth Res Unit, Taejon 305600, South Korea

来源：

PLANTA MEDICA | 1999年 / 65卷 / 05期

关键词：

D O I：

10.1055/s-2006-960803

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A methanolic extract of Commelina communis showed potent inhibitory activity against alpha-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), alpha-homonojirimycin (4) and 7-O-beta-D-glucopyranosyl alpha-homonojirimycin (5) were isolated by bioassay-directed fractionation and separation. These compounds have been identified for the first time from Commelina communis, supporting the pharmacological basis of this plant that has been used as a traditional herbal medicine for the treatment of diabetes.

引用

页码：437 / 439

页数：3

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