Novel polymorphism in the 5′-untranslated region of the interleukin-4 gene

被引：33

作者：

Takabayashi, A

Ihara, K

Sasaki, Y

Kusuhara, K

Nishima, S

Hara, T

机构：

[1] Kyushu Univ, Dept Pediat, Higashi Ku, Fukuoka 8128582, Japan

[2] Natl Minami Fukuoka Chest Hosp, Fukuoka, Japan

来源：

JOURNAL OF HUMAN GENETICS | 1999年 / 44卷 / 05期

关键词：

interleukin-4; gene; polymorphism; atopic asthma; translation;

D O I：

10.1007/s100380050176

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We found a novel polymorphism CIT change at position -34 counting from the first ATG codon, of the interleukin-4 (IL-4) gene, located between the TATA box and the first ATG on exon 1. The allelic frequency of this CIT polymorphism in 64 independent Japanese samples was 0.37:0.63. In addition, PCR-restriction fragment length polymorphism analysis revealed that the -34T/T polymerphism was always associated with -590T/T, a known polymorphism that increases IL-4 transcriptional activity.

引用

页码：352 / 353

页数：2

共 5 条

[1] A common genetic polymorphism (46 C to T substitution) in the 5′-untranslated region of the coagulation factor XII gene is associated with low translation efficiency and decrease in plasma factor XII level [J].