Study of different criteria for the selection of a rugged optimum in high performance liquid chromatography optimisation

被引：18

作者：

deAguiar, PF ^{[1
]}

VanderHeyden, Y ^{[1
]}

Massart, DL ^{[1
]}

机构：

[1] FREE UNIV BRUSSELS,CHEMOAC,FARMACEUT INST,B-1090 BRUSSELS,BELGIUM

来源：

ANALYTICA CHIMICA ACTA | 1997年 / 348卷 / 1-3期

关键词：

optimisation; ruggedness; pareto optimality; Derringer's desirability function; Window Selection Diagram; Multi Criterion Decision Making (MCDM);

D O I：

10.1016/S0003-2670(97)00068-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Some criteria to select acceptably good and rugged conditions when optimising separations in High Performance Liquid Chromatography (HPLC) are discussed and evaluated. These criteria take into account the separation between the least separated pair of peaks, and the ruggedness of the optimisation criterion around each possible optimum. It is also shown that the optimal conditions selected by the criteria are also Pareto-optimal and in agreement with the ones selected when applying Derringer's desirability function.

引用

页码：223 / 235

页数：13

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