Synthetically defined glycoprotein vaccines: current status and future directions

被引：139

作者：

Adamo, Roberto ^{[1
]}

Nilo, Alberto ^{[1
]}

Castagner, Bastien ^{[2
]}

Boutureira, Omar ^{[3
]}

Berti, Francesco ^{[1
]}

Bernardes, Gonalo J. L. ^{[4
,5
]}

机构：

[1] Novartis Vaccines & Diagnost, Res Ctr, I-53100 Siena, Italy

[2] ETH, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

[3] Univ Rovira & Virgili, Deptt Quim Analit & Quim Organ, E-43007 Tarragona, Spain

[4] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[5] Univ Lisbon, Fac Med, Inst Mol Med, P-1649028 Lisbon, Portugal

来源：

CHEMICAL SCIENCE | 2013年 / 4卷 / 08期

关键词：

SOLID-PHASE SYNTHESIS; BREAST-CANCER PATIENTS; CONJUGATE VACCINE; OLIGOSACCHARIDE SYNTHESIS; IMMUNOLOGICAL EVALUATION; CHEMOENZYMATIC SYNTHESIS; CLOSTRIDIUM-DIFFICILE; IMMUNE-RESPONSES; ANTIBODIES; GLYCOPEPTIDE;

D O I：

10.1039/c3sc50862e

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.

引用

页码：2995 / 3008

页数：14

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