The bone marrow niche for haematopoietic stem cells

被引：1713

作者：

Morrison, Sean J. ^{[1
]}

Scadden, David T. ^{[2
,3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Childrens Res Inst, Dept Pediat, Dallas, TX 75390 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Harvard Stem Cell Inst, Ctr Regenerat Med, Cambridge, MA 02138 USA

[3] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

NATURE | 2014年 / 505卷 / 7483期

基金：

美国国家卫生研究院;

关键词：

SLAM FAMILY MARKERS; SELF-RENEWAL; N-CADHERIN; MICE LACKING; STEM/PROGENITOR CELLS; ENDOTHELIAL-CELLS; PROGENITOR CELLS; STROMAL CELLS; FACTOR-I; RECEPTOR;

D O I：

10.1038/nature12984

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis provides a model for understanding mammalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletely defined and beset by competing models. Recent progress has been made in elucidating the location and cellular components of the HSC niche in the bone marrow. The niche is perivascular, created partly by mesenchymal stromal cells and endothelial cells and often, but not always, located near trabecular bone. Outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.

引用

页码：327 / 334

页数：8

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