Benzodiazepine receptor function in the chick social separation-stress procedure

被引:28
作者
Watson, GS
Roach, JT
Sufka, KJ [1 ]
机构
[1] Univ Mississippi, Dept Psychol, University, MS 38677 USA
[2] Univ Mississippi, Dept Pharmacol, University, MS 38677 USA
关键词
D O I
10.1037/1064-1297.7.2.83
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
The role of benzodiazepine (BZ) receptors in modulating social separation-induced distress vocalizations (DVocs) and stress-induced analgesia (SIA) were examined in 8-day-old cockerels (Gallus gallus). Tn Experiment 1, the BZ agonist chlordiazepoxide (CDP; 5.0 mg/kg) reversed both DVocs and SIA in isolated chicks. Coadministration of the BZ antagonist flumazenil (0.01, 0.03, or 0.10 mg/kg) reversed CDP anxiolytic effects. In Experiment 2, the BZ agonists alprazolam (ALP; 0.065, 0.125, 0.25, or 0.50 mg/kg) and lorazepam (LOR; 0.125, 0.25, 0.50, or 1.0 mg/kg) dose dependently reversed social separation-induced DVocs and SIA. The ED(50)s for ALP and LOR in attenuating DVocs were 0.19 and 0.34 mg/kg, respectively. These data strongly support the theory that CDP anxiolytic effects are mediated by BZ receptor activity in the chick social separation procedure (Experiment 1) and that this model is sensitive to BZ agonists of different potencies (Experiment 2).
引用
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页码:83 / 89
页数:7
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