Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety

被引：31

作者：

Adhikari, Adithya ^{[1
]}

Kalluraya, Balakrishna ^{[1
]}

Sujith, Kizhakke Veedu ^{[1
]}

Gouthamchandra, Kuluvar ^{[2
]}

Jairam, Ravikumar ^{[3
]}

Mahmood, Riaz ^{[2
]}

Sankolli, Ravish ^{[4
]}

机构：

[1] Mangalore Univ, Dept Studies Chem, Mangalagangothri 574199, Karnataka, India

[2] Kuvempu Univ, Dept PG Studies & Res Biotechnol & Bioinformat, Shankaraghatta 577451, Karnataka, India

[3] NGSM Inst Pharmaceut Sci, Dept Pharmacol, Deralakkatte 574160, Karnataka, India

[4] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷

关键词：

2-Pyrazolines; XRD studies; Antioxidant; Anti-inflammatory and analgesic activity; REGIOSELECTIVE REACTION SYNTHESIS; ANTIINFLAMMATORY ACTIVITY; 3,5-DIARYL PYRAZOLINES; MANNICH-BASES; DERIVATIVES; INHIBITORS;

D O I：

10.1016/j.ejmech.2012.07.002

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A series of 5-bromo-2-(3,5-diaryl-4,5-dihydro-1H-Pyrazol-1-yl)pyrimidine were prepared under conventional heating as well as microwave reaction condition. The newly synthesized compounds were characterized on the basis of elemental, spectral and single crystal X-ray studies. These new compounds were screened for their antioxidant, anti-inflammatory and analgesic activities. Some of these compounds exhibited potent biological activities compared to the standard drug. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：467 / 474

页数：8

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