T cell immunity to glatiramer acetate ameliorates cognitive deficits induced by chronic cerebral hypoperfusion by modulating the microenvironment

被引：21

作者：

Chen, Li ^{[1
,2
]}

Yao, Yang ^{[1
,2
]}

Wei, Changjuan ^{[1
,2
]}

Sun, Yanan ^{[1
,2
]}

Ma, Xiaofeng ^{[1
,2
]}

Zhang, Rongxin ^{[3
]}

Xu, Xiaolin ^{[4
]}

Hao, Junwei ^{[1
,2
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Dept Neurol, Tianjin 300052, Peoples R China

[2] Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Tianjin 300052, Peoples R China

[3] Tianjin Med Univ, Ctr Basic Med Sci Res, Tianjin 300070, Peoples R China

[4] Tianjin Huanhu Hosp, Dept Neurol, Tianjin 300060, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

芬兰科学院; 中国国家自然科学基金;

关键词：

ALZHEIMERS-DISEASE; CHOLINE-ACETYLTRANSFERASE; NEUROTROPHIC FACTOR; PROTECTIVE AUTOIMMUNITY; NEURONAL DAMAGE; TH2; CELLS; BRAIN; MICE; GLUTAMATE; MEMORY;

D O I：

10.1038/srep14308

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Vascular dementia (VaD) is a progressive and highly prevalent disorder. However, in a very large majority of cases, a milieu of cellular and molecular events common for multiple neurodegenerative diseases is involved. Our work focused on whether the immunomodulating effect of glatiramer acetate (GA) could restore normalcy to the microenvironment and ameliorate cognitive decline induced by chronic cerebral hypoperfusion. We assessed cognitive function by rats' performance in a Morris water maze (MWM), electrophysiological recordings and by pathologic changes. The results suggest that GA reduced cognitive deficits by reestablishing an optimal microenvironment such as increasing expression of the brain-derived neurotrophic factor (BDNF) and modulating the Th1/Th2 cytokine balance in the hippocampus. When microenvironmental homeostasis is restored, cholinergic activity becomes involved in ameliorating cellular damage. Since vaccination with GA can boost "protective autoimmunity" in this way, a similar strategy may have therapeutic potential for alleviating VaD disease.

引用

页数：11

共 65 条

[1]

Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1 [J].