TEAD mediates YAP-dependent gene induction and growth control

被引：2238

作者：

Zhao, Bin ^{[1
,2
,3
]}

Ye, Xin ^{[4
,5
]}

Yu, Jindan

Li, Li ^{[1
,2
,3
]}

Li, Weiquan ^{[6
]}

Li, Siming ^{[6
]}

Yu, Jianjun

Lin, Jiandie D. ^{[6
]}

Wang, Cun-Yu ^{[7
]}

Chinnaiyan, Arul M.

Lai, Zhi-Chun ^{[4
,5
]}

Guan, Kun-Liang ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[3] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

[4] Penn State Univ, Dept Biol, University Pk, PA 16802 USA

[5] Penn State Univ, Intercoll Grad Program Genet, University Pk, PA 16802 USA

[6] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[7] Univ Calif Los Angeles, Sch Dent, Mol Signalling Lab, Div Oral Biol & Med, Los Angeles, CA 90095 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 14期

关键词：

TEAD; YAP; CTGF; Hippo; transcription; cancer;

D O I：

10.1101/gad.1664408

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.

引用

页码：1962 / 1971

页数：10

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