Combined Effects of Antenatal Receipt of Influenza Vaccine by Mothers and Pneumococcal Conjugate Vaccine Receipt by Infants: Results from a Randomized, Blinded, Controlled Trial

被引：17

作者：

Omer, Saad B. ^{[1
,2
,3
]}

Zaman, Khalequ ^{[6
]}

Roy, Eliza ^{[6
]}

Arifeen, Shams E. ^{[6
]}

Raqib, Rubhana ^{[6
]}

Noory, Laila ^{[1
]}

Seib, Katherine ^{[1
]}

Breiman, Robert F. ^{[7
]}

Steinhoff, Mark C. ^{[4
,5
]}

机构：

[1] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Atlanta, GA 30322 USA

[3] Kaiser Permanente Georgia, Ctr Hlth Res Southeast, Atlanta, GA USA

[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[5] Cincinnati Childrens Hosp, Global Hlth Ctr, Cincinnati, OH USA

[6] ICDDRB, Dhaka, Bangladesh

[7] US Ctr Dis Control & Prevent, Nairobi, Kenya

来源：

JOURNAL OF INFECTIOUS DISEASES | 2013年 / 207卷 / 07期

关键词：

Influenza vaccine; pregnancy; pneumococcal conjugate vaccine; influenza-like illness; VIRUS; IMMUNIZATION; PREGNANCY;

D O I：

10.1093/infdis/jit003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A 2 x 2 factorial trial was performed to determine the efficacy of antennal influenza vaccination of mothers plus pneumococcal conjugate vaccination of their infants against respiratory illness during early infancy. The efficacy of trivalent inactivated influenza vaccine (TIV; delivered to mothers) plus 7-valent pneumococcal vaccine (PCV7; delivered to infants) was higher than the efficacy of TIV alone or PCV7 alone. During the period of the study in which influenza was circulating, the efficacy of TIV plus PCV7 was 72.4% (95% confidence interval, 30.2%-89.1%) against febrile respiratory illness and 66.4% (95% CI, 14.3%-86.9%) against medically attended acute respiratory illness. Clinical Trials registration NCT00142389.

引用

页码：1144 / 1147

页数：4

共 15 条

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