Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review

被引:379
作者
Cor, Darija [1 ]
Knez, Zeljko [1 ,2 ]
Hrncic, Masa Knez [1 ]
机构
[1] Univ Maribor, Fac Chem & Chem Engn, SI-2000 Maribor, Slovenia
[2] Univ Maribor, Fac Med, SI-2000 Maribor, Slovenia
关键词
biological activity; triterpenoids; polyscaccharides; G; lucidum; NF-KAPPA-B; INHIBITS TUMOR INVASION; ACIDS SUPPRESS GROWTH; BREAST-CANCER CELLS; IN-VITRO; ANTIHERPETIC ACTIVITIES; MOLECULAR-WEIGHT; FRUITING BODIES; DENDRITIC CELLS; ANTLERED FORM;
D O I
10.3390/molecules23030649
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Ganoderma lucidum (Reishi) is a popular medicinal mushroom and has been used in oriental medicine because of its promoting effects on health and life expectancy. G. lucidum contains various compounds with a high grade of biological activty, which increase the immunity and show antitumour, antimicrobial, anti-inflammatory, antioxidant and acetylcholinesterase inhibitory activity. Several of these substances belong to the triterpenoids and polysaccharides classes. Proteins, lipids, phenols, sterols, etc. are also present. In the present review, an extensive overview of the presence of antitumour, antimicrobial, antioxidant and antiacetylcholinesterase compounds in G. lucidum extracts will be given, along with an evaluation of their therapeutic effects.
引用
收藏
页数:21
相关论文
共 103 条
[1]
Effect of Ganoderma lucidum on the activities of mitochondrial dehydrogenases and complex I and II of electron transport chain in the brain of aged rats [J].
Ajith, T. A. ;
Sudheesh, N. P. ;
Roshny, D. ;
Abishek, G. ;
Janardhanan, K. K. .
EXPERIMENTAL GERONTOLOGY, 2009, 44 (03) :219-223
[2]
Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum [J].
Akihisa, Toshihiro ;
Nakamura, Yuji ;
Tagata, Masaaki ;
Tokuda, Harukuni ;
Yasukawa, Ken ;
Uchiyama, Emiko ;
Suzuki, Takashi ;
Kimura, Yumiko .
CHEMISTRY & BIODIVERSITY, 2007, 4 (02) :224-231
[3]
Babu P D., 2008, American-Eurasian Journal of Botany, V1, P107
[4]
Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst [J].
Bao, XF ;
Liu, CP ;
Fang, JN ;
Li, XY .
CARBOHYDRATE RESEARCH, 2001, 332 (01) :67-74
[5]
Probing Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes): A Bitter Mushroom with Amazing Health Benefits [J].
Batra, Priya ;
Sharma, Anil Kumar ;
Khajuria, Robinka .
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS, 2013, 15 (02) :127-143
[6]
From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals [J].
Bishop, Karen S. ;
Kao, Chi H. J. ;
Xu, Yuanye ;
Glucina, Marcus P. ;
Paterson, R. Russell M. ;
Ferguson, Lynnette R. .
PHYTOCHEMISTRY, 2015, 114 :56-65
[7]
Boh B, 2007, BIOTECHNOL ANN REV, V13, P265, DOI 10.1016/S1387-2656(07)13010-6
[8]
Buchman V. M., 2007, Antibiotiki i Khimioterapiya, V52, P4
[9]
Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides [J].
Cao, LZ ;
Lin, ZB .
IMMUNOLOGY LETTERS, 2002, 83 (03) :163-169
[10]
Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley [J].
Chan, Wing Keung ;
Law, Helen Ka Wai ;
Lin, Zhi-Bin ;
Lau, Yu Lung ;
Chan, Godfrey Chi-Fung .
INTERNATIONAL IMMUNOLOGY, 2007, 19 (07) :891-899