Molecular genetic characterisation of frontotemporal dementia on chromosome 3

被引：25

作者：

Ashworth, A

Lloyd, S

Brown, J

Gydesen, S

Sorensen, SA

Brun, A

Englund, E

Humphreys, C

Housman, D

Badura, M

Stanton, V

Taylor, K

Cameron, J

Munroe, D

Johansson, J

Rossor, M

Fisher, EMC

Collinge, J

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Neurogenet, London W2 1PG, England

[2] Queen Elizabeth Hosp, Kings Lynn, England

[3] Addenbrookes Hosp, Dept Neurol, Cambridge, England

[4] Univ Copenhagen, Panum Inst, Dept Med Genet, DK-1168 Copenhagen, Denmark

[5] Univ Lund Hosp, Dept Neuropathol, S-22185 Lund, Sweden

[6] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

[7] UCL, Dept Genet, London WC1E 6BT, England

[8] Sequana Therapeut Inc, La Jolla, CA USA

[9] Umea Univ Hosp, Dept Clin Genet, S-90185 Umea, Sweden

[10] St Marys Hosp, Dept Neurol, London, England

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 1999年 / 10卷

关键词：

frontal robe dementia; familial nonspecific dementia; anticipation; trinucleotide repeat;

D O I：

10.1159/000051222

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. Th is pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion involvement. We also outline our strategies to clone the mutant gene via its putative associated trinucleotide repeat sequence.

引用

页码：93 / 101

页数：9

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