The role of early life viral bronchiolitis in the inception of asthma

被引:61
作者
Beigelman, Avraham
Bacharier, Leonard B.
机构
[1] Washington Univ, Dept Pediat, St Louis, MO 63110 USA
[2] St Louis Childrens Hosp, St Louis, MO 63178 USA
关键词
asthma; respiratory syncytial virus; rhinovirus; viral bronchiolitis; wheeze; RESPIRATORY SYNCYTIAL VIRUS; WHEEZING RHINOVIRUS ILLNESSES; VITAMIN-D DEFICIENCY; CHILDHOOD ASTHMA; TRACT INFECTIONS; URBAN CHILDREN; LUNG-FUNCTION; MOUSE MODEL; RISK; DISEASE;
D O I
10.1097/ACI.0b013e32835eb6ef
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Propose of review Cumulative evidence suggest that early life bronchiolitis is a major risk factor for subsequent wheezing episodes and asthma. The purpose of this review is to present the recent findings and current perspectives regarding the interplay between bronchiolitis and long-term respiratory outcomes. Recent findings Recent studies have supported the long-recognized link between early life severe respiratory syncytial virus bronchiolitis and the physician diagnosis of asthma by school age, and this association appears to continue into early adulthood. Evidence is accumulating regarding the role of early life infection with human rhinovirus as an important antecedent for future asthma. Whether viral bronchiolitis is causal or an early manifestation of future asthma remains uncertain. Vitamin D status has emerged as a potential modifying factor for viral-induced wheeze and could potentially influence the development of asthma. Summary Viral bronchiolitis early in life is a major and potential long-term risk factor for subsequent wheezing and asthma. Whether the association between bronchiolitis and subsequent asthma is due to causality or a reflection of predisposition may be dependent on host factors and virus-specific effects.
引用
收藏
页码:211 / 216
页数:6
相关论文
共 46 条
  • [1] Shifting of Immune Responsiveness to House Dust Mite by Influenza A Infection: Genomic Insights
    Al-Garawi, Amal
    Husain, Mainul
    Ilieva, Dora
    Humbles, Alison A.
    Kolbeck, Roland
    Stampfli, Martin R.
    O'Byrne, Paul M.
    Coyle, Anthony J.
    Jordana, Manel
    [J]. JOURNAL OF IMMUNOLOGY, 2012, 188 (02) : 832 - 843
  • [2] Determinants of asthma after severe respiratory syncytial virus bronchiolitis
    Bacharier, Leonard B.
    Cohen, Rebecca
    Schweiger, Toni
    Yin-DeClue, Huiquing
    Christie, Chandrika
    Zheng, Jie
    Schechtman, Kenneth B.
    Strunk, Robert C.
    Castro, Mario
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (01) : 91 - +
  • [3] Cord Blood Vitamin D Deficiency Is Associated With Respiratory Syncytial Virus Bronchiolitis
    Belderbos, Mirjam E.
    Houben, Michiel L.
    Wilbrink, Berry
    Lentjes, Eef
    Bloemen, Eltje M.
    Kimpen, Jan L. L.
    Rovers, Maroeska
    Bont, Louis
    [J]. PEDIATRICS, 2011, 127 (06) : E1513 - E1520
  • [4] Traffic-Related Pollutants and Wheezing in Children
    Bernstein, David I.
    [J]. JOURNAL OF ASTHMA, 2012, 49 (01) : 5 - 7
  • [5] Brehm JM, 2012, AM J RESP CRIT CARE
  • [6] Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study
    Brehm, John M.
    Schuemann, Brooke
    Fuhlbrigge, Anne L.
    Hollis, Bruce W.
    Strunk, Robert C.
    Zeiger, Robert S.
    Weiss, Scott T.
    Litonjua, Augusto A.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 126 (01) : 52 - 58
  • [7] Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica
    Brehm, John M.
    Celedon, Juan C.
    Soto-Quiros, Manuel E.
    Avila, Lydiana
    Hunninghake, Gary M.
    Forno, Erick
    Laskey, Daniel
    Sylvia, Jody S.
    Hollis, Bruce W.
    Weiss, Scott T.
    Litonjua, Augusto A.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179 (09) : 765 - 771
  • [8] Cord-Blood 25-Hydroxyvitamin D Levels and Risk of Respiratory Infection, Wheezing, and Asthma
    Camargo, Carlos A., Jr.
    Ingham, Tristram
    Wickens, Kristin
    Thadhani, Ravi
    Silvers, Karen M.
    Epton, Michael J.
    Town, G. Ian
    Pattemore, Philip K.
    Espinola, Janice A.
    Crane, Julian
    [J]. PEDIATRICS, 2011, 127 (01) : E180 - E187
  • [9] Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections
    Carroll, Kecia N.
    Gebretsadik, Tebeb
    Minton, Patricia
    Woodward, Kimberly
    Liu, Zhouwen
    Miller, E. Kathryn
    Williams, John V.
    Dupont, William D.
    Hartert, Tina V.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (05) : 1236 - 1242
  • [10] The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma
    Carroll, Kecia N.
    Wu, Pingsheng
    Gebretsadik, Tebeb
    Griffin, Marie R.
    Dupont, William D.
    Mitchel, Edward F.
    Hartert, Tina V.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (05) : 1055 - 1061