Physics of size selectivity

被引:54
作者
Roth, R
Gillespie, D
机构
[1] Max Planck Inst Met Res, D-70569 Stuttgart, Germany
[2] Univ Stuttgart, ITAP, D-70569 Stuttgart, Germany
[3] Rush Univ, Med Ctr, Dept Mol Biophys & Physiol, Chicago, IL 60612 USA
关键词
D O I
10.1103/PhysRevLett.95.247801
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
We demonstrate that two mechanisms used by biological ion channels to select particles by size are driven by entropy. With uncharged particles in an infinite cylinder, we show that a channel that attracts particles is small-particle selective and that a channel that repels water from the wall is large-particle selective. Comparing against the extensive density-functional theory calculations of our model, we find that the main physics can be understood with surprisingly simple bulk models that neglect the confining geometry of the channel completely.
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页数:4
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