Role of angiotensin converting enzyme genotype in sodium sensitivity in older hypertensives

被引:24
作者
Dengel, DR
Brown, MD
Ferrell, RE
Supiano, MA
机构
[1] Univ Minnesota, Sch Kinesiol & Leisure Studies, Minneapolis, MN 55455 USA
[2] Minneapolis Vet Affairs Med Ctr, Minneapolis, MN USA
[3] Univ Michigan, Dept Internal Med, Div Geriatr Med, Ann Arbor, MI 48109 USA
[4] Ann Arbor Vet Affairs Med Ctr, GRECC, Ann Arbor, MI USA
[5] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA
关键词
ACE gene; aging; blood pressure; genetics; hypertension;
D O I
10.1016/S0895-7061(01)02204-X
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background: Individuals differ in their blood pressure (BP) response to changes in dietary sodium (Na+) intake. It is possible that differences in BP responses to dietary Na+ are influenced by genes. Methods: A total of 35 older (62.9 +/- 1.2 years) hypertensive subjects had their mean arterial blood pressure (MABP) determined after 8 days of low (20 mmol/day) and high (200 mmol/day) Na+ intake. The insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene was genotyped with standard polymerase chain reaction methods. Results: Of the 35 subjects. 24 were classified as sodium-sensitive (greater than or equal to5 turn Hg increase in MABP in response to the increase in dietary Na+) and 11 were classified as sodium-resistant (<5 mm Hg increase in MABP). Those homozygous for the insertion allele of the ACE gene (insertion/insertion [II] n = 8) had lower (P = .04) MABP responses to the increase in dietary Na+ (0 +/- 3 nim Hg) compared to heterozygotes (insertion/deletion [ID] n = 20) (9 +/- 2 min Hg P = .0001) and those homozygous for the deletion allele (deletion/deletion [DD] n = 7) (9 +/- 3 min Hg P = .05). The prevalence of sodium sensitivity was higher (P = .0083) in DD (71%) and ID (83%) compared to II (25%) genotype groups. Conclusions: Based on these data in older hypertensive individuals, we conclude that the ACE gene ID and DD genotypes are associated with an increase in BP during a high Na+ diet, which is consistent with the phenotypic characteristic of sodium sensitivity. (C) 2001 American Journal of Hypertension, Ltd.
引用
收藏
页码:1178 / 1184
页数:7
相关论文
共 37 条
[1]  
Buikema H, 1996, EUR HEART J, V17, P787
[2]   DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans [J].
Butler, R ;
Morris, AD ;
Burchell, B ;
Struthers, AD .
HYPERTENSION, 1999, 33 (05) :1164-1168
[3]   DELETION POLYMORPHISM IN THE GENE FOR ANGIOTENSIN-CONVERTING ENZYME IS A POTENT RISK FACTOR FOR MYOCARDIAL-INFARCTION [J].
CAMBIEN, F ;
POIRIER, O ;
LECERF, L ;
EVANS, A ;
CAMBOU, JP ;
ARVEILER, D ;
LUC, G ;
BARD, JM ;
BARA, L ;
RICARD, S ;
TIRET, L ;
AMOUYEL, P ;
ALHENCGELAS, F ;
SOUBRIER, F .
NATURE, 1992, 359 (6396) :641-644
[4]   Fluid, ionic and hormonal changes induced by high salt intake in salt-sensitive and salt-resistant hypertensive patients [J].
delaSierra, A ;
delMarLluch, M ;
Coca, A ;
Aguilera, MT ;
Giner, V ;
Bragulat, E ;
UrbanoMarquez, A .
CLINICAL SCIENCE, 1996, 91 (02) :155-161
[5]   Insulin sensitivity is associated with blood pressure response to sodium in older hypertensives [J].
Dengel, DR ;
Hogikyan, RV ;
Brown, MD ;
Glickman, SG ;
Supiano, MA .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1998, 274 (03) :E403-E409
[6]  
DRAAIJER P, 1993, J HYPERTENS, V11, P1199
[7]  
ELLIOTT P, 1988, BRIT MED J, V297, P319
[8]  
Ferrari P, 1992, Blood Press, V1, P86, DOI 10.3109/08037059209077498
[9]  
Gerdts E, 1994, Blood Press, V3, P375, DOI 10.3109/08037059409102290
[10]   Renin-angiotensin system genetic polymorphisms and salt sensitivity in essential hypertension [J].
Giner, V ;
Poch, E ;
Bragulat, E ;
Oriola, J ;
González, D ;
Coca, A ;
de la Sierra, A .
HYPERTENSION, 2000, 35 (01) :512-517