The nature of the starter unit for the rapamycin polyketide synthase

被引:27
作者
Lowden, PAS
Bohm, GA
Staunton, J
Leadlay, PF
机构
[1] UNIV CAMBRIDGE,DEPT CHEM,CAMBRIDGE CB2 1EW,ENGLAND
[2] UNIV CAMBRIDGE,DEPT BIOCHEM,CAMBRIDGE CB2 1QW,ENGLAND
来源
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1996年 / 35卷 / 19期
关键词
D O I
10.1002/anie.199622491
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:2249 / 2251
页数:3
相关论文
共 22 条
[1]   Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase [J].
Aparicio, JF ;
Molnar, I ;
Schwecke, T ;
Konig, A ;
Haydock, SF ;
Khaw, LE ;
Staunton, J ;
Leadlay, PF .
GENE, 1996, 169 (01) :9-16
[2]   ENANTIOSELECTIVE SYNTHESIS OF THE C(18)-C(35) SEGMENT OF IMMUNOSUPPRESSANT FK-506 USING EFFICIENT NEW METHODOLOGY [J].
COREY, EJ ;
HUANG, HC .
TETRAHEDRON LETTERS, 1989, 30 (39) :5235-5238
[3]   AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].
CORTES, J ;
HAYDOCK, SF ;
ROBERTS, GA ;
BEVITT, DJ ;
LEADLAY, PF .
NATURE, 1990, 348 (6297) :176-178
[4]   AN ERYTHROMYCIN ANALOG PRODUCED BY REPROGRAMMING OF POLYKETIDE SYNTHESIS [J].
DONADIO, S ;
MCALPINE, JB ;
SHELDON, PJ ;
JACKSON, M ;
KATZ, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :7119-7123
[5]   MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS [J].
DONADIO, S ;
STAVER, MJ ;
MCALPINE, JB ;
SWANSON, SJ ;
KATZ, L .
SCIENCE, 1991, 252 (5006) :675-679
[6]   Mechanism of action of the immunosuppressant rapamycin [J].
Dumont, FJ ;
Su, QX .
LIFE SCIENCES, 1995, 58 (05) :373-395
[7]   SYNTHESIS OF THE 9,10-ACETONIDE OF 9-DIHYDRO-FK-506 [J].
IRELAND, RE ;
HIGHSMITH, TK ;
GEGNAS, LD ;
GLEASON, JL .
JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (19) :5071-5073
[8]   MANIPULATION OF MACROLIDE RING SIZE BY DIRECTED MUTAGENESIS OF A MODULAR POLYKETIDE SYNTHASE [J].
KAO, CM ;
LUO, GL ;
KATZ, L ;
CANE, DE ;
KHOSLA, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (35) :9105-9106
[9]   STRUCTURE-ACTIVITY STUDIES OF RAPAMYCIN ANALOGS - EVIDENCE THAT THE C-7 METHOXY GROUP IS PART OF THE EFFECTOR DOMAIN AND POSITIONED AT THE FKBP12-FRAP INTERFACE [J].
LUENGO, JI ;
YAMASHITA, DS ;
DUNNINGTON, D ;
BECK, AK ;
ROZAMUS, LW ;
YEN, HK ;
BOSSARD, MJ ;
LEVY, MA ;
HAND, A ;
NEWMANTARR, T ;
BADGER, A ;
FAUCETTE, L ;
JOHNSON, RK ;
DALESSIO, K ;
PORTER, T ;
SHU, AYL ;
HEYS, R ;
CHOI, JW ;
KONGSAEREE, P ;
CLARDY, J ;
HOLT, DA .
CHEMISTRY & BIOLOGY, 1995, 2 (07) :471-481
[10]   REVISED NMR ASSIGNMENTS FOR RAPAMYCIN [J].
MCALPINE, JB ;
SWANSON, SJ ;
JACKSON, M ;
WHITTERN, DN .
JOURNAL OF ANTIBIOTICS, 1991, 44 (06) :688-690