T1ρ and T2 relaxation times predict progression of knee osteoarthritis

被引:120
作者
Prasad, A. P. [1 ]
Nardo, L. [1 ]
Schooler, J. [1 ]
Joseph, G. B. [1 ]
Link, T. M. [1 ]
机构
[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, Musculoskeletal & Quantitat Imaging Res Grp, San Francisco, CA 94143 USA
关键词
Osteoarthritis; T-2; T-1; rho; Progression; Magnetic resonance imaging; CARTILAGE T2 MEASUREMENTS; ARTICULAR-CARTILAGE; PHYSICAL-ACTIVITY; ASYMPTOMATIC SUBJECTS; RHEUMATOID-ARTHRITIS; ASSOCIATION; SEVERITY; ABNORMALITIES; INCREASES; MENISCUS;
D O I
10.1016/j.joca.2012.09.011
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
100224 [整形外科学];
摘要
Objective: To evaluate whether T-2 and T-1 rho relaxation times of knee cartilage determined with 3T magnetic resonance imaging (MRI) at baseline predict longitudinal progression of cartilage degenerative changes. Methods: Quantitative analysis of cartilage was performed using 31 MRI with both T-2 and T-1 rho mapping techniques in 55 subjects without evidence of severe osteoarthritis (OA) [Kellgren-Lawrence (KL) score of 0-3] at baseline. Morphological abnormalities of cartilage, menisci, ligaments and bone marrow were analyzed on sagittal fat-saturated intermediate-weighted fast spin echo (FSE) sequences. Progression of degenerative changes was analyzed over a period of 2 years. Progression was detected in 27 subjects while in 28 subjects no changes were found. Differences between T-2 and T-1 rho relaxation times in these two cohorts were compared using one-way analysis of variance (ANOVA) and t tests. Results: Baseline T-2 and T-1 rho values were significantly higher in the progression cohort in all compartments (P < 0.05) except the lateral tibia (LT) for T-2 and the medial tibia (MT) for T-1 rho. Progression of cartilage degenerative disease was most pronounced at the medial femoral condyles and at the femoro-patellar joint; differences between the two cohorts for T-2 and T-1 rho were also most significant in these compartments. Conclusions: T-2 and T-1 rho measurements were significantly higher at baseline in individuals that showed progression of cartilage abnormalities over a period of 2 years and may therefore serve as potential predictors for progression of degenerative cartilage abnormalities in knee OA. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:69 / 76
页数:8
相关论文
共 40 条
[1]
[Anonymous], 1997, PHYS CHEMESTRY EMGIN, DOI DOI 10.1121/1.418074
[2]
[Anonymous], ADV MRI KNEE OSTEOAR
[3]
Baum T, 2012, ARTHRITIS CARE RES H
[4]
Association of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with knee pain: Data from the Osteoarthritis Initiative [J].
Baum, Thomas ;
Joseph, Gabby B. ;
Arulanandan, Ahilan ;
Nardo, Lorenzo ;
Virayavanich, Warapat ;
Carballido-Gamio, Julio ;
Nevitt, Michael C. ;
Lynch, John ;
McCulloch, Charles E. ;
Link, Thomas M. .
ARTHRITIS CARE & RESEARCH, 2012, 64 (02) :248-255
[5]
Spatial analysis of magnetic resonance T1ρ and T2 relaxation times improves classification between subjects with and without osteoarthritis [J].
Carballido-Gamio, Julio ;
Stahl, Robert ;
Blumenkrantz, Gabrielle ;
Romero, Adan ;
Majumdar, Sharmila ;
Link, Thomas M. .
MEDICAL PHYSICS, 2009, 36 (09) :4059-4067
[6]
Detecting radiographic knee osteoarthritis: what combination of views is optimal? [J].
Chaisson, CE ;
Gale, DR ;
Gale, E ;
Kazis, L ;
Skinner, K ;
Felson, DT .
RHEUMATOLOGY, 2000, 39 (11) :1218-1221
[7]
Articular Cartilage in the Knee: Current MR Imaging Techniques and Applications in Clinical Practice and Research [J].
Crema, Michel D. ;
Roemer, Frank W. ;
Marra, Monica D. ;
Burstein, Deborah ;
Gold, Garry E. ;
Eckstein, Felix ;
Baum, Thomas ;
Mosher, Timothy J. ;
Carrino, John A. ;
Guermazi, Ali .
RADIOGRAPHICS, 2011, 31 (01) :37-U76
[8]
T2 relaxation time measurements in osteoarthritis [J].
David-Vaudey, E ;
Ghosh, S ;
Ries, M ;
Majumdar, S .
MAGNETIC RESONANCE IMAGING, 2004, 22 (05) :673-682
[9]
T2 relaxation time of cartilage at MR imaging: Comparison with severity of knee osteoarthritis [J].
Dunn, TC ;
Lu, Y ;
Jin, H ;
Ries, MD ;
Majumdar, S .
RADIOLOGY, 2004, 232 (02) :592-598
[10]
Elahi S, 2000, ARTHRITIS RHEUM, V43, P1874, DOI 10.1002/1529-0131(200008)43:8<1874::AID-ANR25>3.0.CO