Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?

被引：60

作者：

Thomas, R

Lipsky, PE

机构：

[1] UNIV TEXAS,SW MED CTR,HAROLD C SIMMONS ARTHRITIS RES CTR,DALLAS,TX 75235

[2] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DALLAS,TX 75235

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 12期

关键词：

D O I：

10.1016/S0167-5699(96)20030-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The critical interaction initiating and perhaps perpetuating rheumatoid arthritis (RA) is the presentation of arthritogenic antigen to autoreactive T cells. In contrast to many organ-specific autoimmune diseases, no candidate autoantigens have yet been confirmed for RA. Here, Ranjeny Thomas and Peter Lipsky examine the role of dendritic cells in autoimmune disease, leading to the hypothesis that activation of T cells by endogenous self-peptides may be sufficient to initiate RA.

引用

收藏

页码：559 / 564

页数：6

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