Serum levels of circulating adhesion molecules after coronary angioplasty

被引:32
作者
Inoue, T [1 ]
Hoshi, K [1 ]
Yaguchi, I [1 ]
Iwasaki, Y [1 ]
Takayanagi, K [1 ]
Morooka, S [1 ]
机构
[1] Dokkyo Univ, Sch Med, Koshigaya Hosp, Dept Cardiol, Koshigaya, Saitama 3438555, Japan
关键词
coronary angioplasty; vasculature; pathophysiology; angioplasty; restenosis; adhesion molecules;
D O I
10.1159/000006917
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The activation of platelets, leukocytes, and vascular endothelial cells mediated by cell adhesion molecules may play a role in the mechanism of restenosis, which is still a significant complication after coronary angioplasty. We observed serial changes in the circulating soluble forms of adhesion molecules in 25 patients with coronary artery disease who underwent coronary angioplasty for a single lesion of the left anterior descending artery. Serum levels of sICAM-1 (p < 0.05) and sP-selectin (p < 0.05) were significantly increased immediately after angioplasty in the coronary sinus blood samples. These increases continued during the 48-hour observation period, and the maximum increase was seen 48 h after angioplasty for sICAM-1 (p < 0.01) and 24 h after angioplasty for sP-selectin (p < 0.01). The level of sL-selectin increased 24 h (p < 0.01) and 48 h (p < 0.001) after angioplasty. These changes were not observed in the peripheral blood samples. The sE-selectin level did not change after angioplasty, A multiple regression analysis showed that the late loss index obtained from quantitative angiographic (QCA) analysis was correlated with the changes in sICAM-1 (r = 0.31, p < 0.05), sl-selectin (r = 0.28, p < 0.05), and sP-selectin (r = 0.26, p < 0.05) 48 h after angioplasty in the coronary sinus blood samples, but was not correlated with procedural variables, other OCA variables, or the change in the sL-selectin level. The measurements of these adhesion molecule levels may help to evaluate traumatic vessel wall injury and inflammation at the intervention site after coronary angioplasty.
引用
收藏
页码:236 / 242
页数:7
相关论文
共 32 条
[1]   DETECTION AND LOCALIZATION OF TUMOR NECROSIS FACTOR IN HUMAN ATHEROMA [J].
BARATH, P ;
FISHBEIN, MC ;
CAO, J ;
BERENSON, J ;
HELFANT, RH ;
FORRESTER, JS .
AMERICAN JOURNAL OF CARDIOLOGY, 1990, 65 (05) :297-302
[2]   LEUKOCYTE-ENDOTHELIAL CELL RECOGNITION - 3 (OR MORE) STEPS TO SPECIFICITY AND DIVERSITY [J].
BUTCHER, EC .
CELL, 1991, 67 (06) :1033-1036
[3]  
CLOWES AW, 1983, LAB INVEST, V49, P327
[4]  
CLOWES AW, 1983, LAB INVEST, V49, P208
[5]   GRANULOCYTE ACTIVATION AFTER CORONARY ANGIOPLASTY IN HUMANS [J].
DESERVI, S ;
MAZZONE, A ;
RICEVUTI, G ;
FIORAVANTI, A ;
BRAMUCCI, E ;
ANGOLI, L ;
STEFANO, G ;
SPECCHIA, G .
CIRCULATION, 1990, 82 (01) :140-146
[6]   A PARADIGM FOR RESTENOSIS BASED ON CELL BIOLOGY - CLUES FOR THE DEVELOPMENT OF NEW PREVENTIVE THERAPIES [J].
FORRESTER, JS ;
FISHBEIN, M ;
HELFANT, R ;
FAGIN, J .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1991, 17 (03) :758-769
[7]   SOLUBLE FORMS OF VASCULAR ADHESION MOLECULES, E-SELECTIN, ICAM-1, AND VCAM-1 - PATHOLOGICAL SIGNIFICANCE [J].
GEARING, AJH ;
HEMINGWAY, I ;
PIGOTT, R ;
HUGHES, J ;
REES, AJ ;
CASHMAN, SJ .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 667 :324-331
[8]   CIRCULATING ADHESION MOLECULES IN DISEASE [J].
GEARING, AJH ;
NEWMAN, W .
IMMUNOLOGY TODAY, 1993, 14 (10) :506-512
[9]  
GROOTE P, 1995, CIRCULATION, V91, P968
[10]   SELECTIN GMP-140 (CD62, PADGEM) BINDS TO SIALOSYL-LEA AND SIALOSYL-LEX, AND SULFATED GLYCANS MODULATE THIS BINDING [J].
HANDA, K ;
NUDELMAN, ED ;
STROUD, MR ;
SHIOZAWA, T ;
HAKOMORI, S .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (03) :1223-1230