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Apoptosis: A link between cancer genetics and chemotherapy

被引：1959
作者：
Johnstone, RW
Ruefli, AA
Lowe, SW
机构：
[1] Peter MacCallum Canc Inst, Canc Immunol Div, Trescowthick Res Labs, Melbourne, Vic 3002, Australia
[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
CELL | 2002年 / 108卷 / 02期
关键词：
D O I：
10.1016/S0092-8674(02)00625-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.
引用
收藏
页码：153 / 164
页数：12
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