An improved total synthesis of PET HSV-tk gene expression imaging agent 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG)

被引：9

作者：

Wang, JQ

Zheng, QH

Fei, XS

Liu, X

Gardner, TA

Kao, CH

Raikwar, SP

Glick-Wilson, BE

Sullivan, ML

Mock, BH

Hutchins, GD

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Urol, Indianapolis, IN 46202 USA

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 05期

关键词：

9-[(3-[F-18]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([F-18]FHPG); ganciclovir (GCV); synthesis; positron emission tomography (PET); herpes simplex virus thymidine kinase (HSV-tk); gene expression;

D O I：

10.1081/SCC-120028365

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved total synthesis of [F-18]FHPG starting from 1,3-dibenzyloxy2-propanol and guanine has been developed. [F-18]FHPG was prepared by nucleophilic substitution of the appropriate precursor with [F-18]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 10-15% radiochemical yield, and 70 min synthesis time from end of bombardment (EOB).

引用

收藏

页码：917 / 932

页数：16

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