Microbiology -: Salmonella strikes a balance

被引:2
作者
Donnenberg, MS [1 ]
机构
[1] Univ Maryland, Dept Med, Baltimore, MD 21201 USA
关键词
D O I
10.1038/45690
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Host cells rarely wish to admit bacterial invaders, butSalmonella has developed a clever way to get around this. It first injects a protein called SopE, which stimulates the host cell's outer membrane to form ruffles and take up the bacterium. Salmonellathen injects another protein, SptP, to reverse these effects, returning the cell to its normal state so that it will survive and can provide a comfortable home for the bacterium.
引用
收藏
页码:218 / 219
页数:2
相关论文
共 6 条
[1]   The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton [J].
Fu, YX ;
Galán, JE .
MOLECULAR MICROBIOLOGY, 1998, 27 (02) :359-368
[2]   A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion [J].
Fu, YX ;
Galán, JE .
NATURE, 1999, 401 (6750) :293-297
[3]   Rho GTPases and the actin cytoskeleton [J].
Hall, A .
SCIENCE, 1998, 279 (5350) :509-514
[4]   S-typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells [J].
Hardt, WD ;
Chen, LM ;
Schuebel, KE ;
Bustelo, XR ;
Galán, JE .
CELL, 1998, 93 (05) :815-826
[5]   The Rho small G protein family Rho GDI system as a temporal and spatial determinant for cytoskeletal control [J].
Sasaki, T ;
Takai, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 245 (03) :641-645
[6]  
TAKEUCHI A, 1967, AM J PATHOL, V50, P109