Pleiotrophin induces expression of inflammatory cytokines in peripheral blood mononuclear cells

被引：22

作者：

Achour, Ammar ^{[1
]}

M'Bika, Jean Pierre ^{[1
]}

Baudouin, Francoise ^{[2
]}

Caruelle, Daniele ^{[3
]}

Courty, Jose ^{[3
]}

机构：

[1] Univ Paris 05, Lab Interferons, UFR Biomed St Peres, F-75006 Paris, France

[2] CHNO Quinze Vingts, Unite Pharmacotoxicol Cellulaire, F-75012 Paris, France

[3] Univ Paris 12, Lab Rech Croissance Cellulaire Reparat & Regenera, UMR 7149, F-94010 Creteil, France

来源：

BIOCHIMIE | 2008年 / 90卷 / 11-12期

关键词：

Heparin factor; Pleiotrophin; Cytokines; Inflammation; Endothelium;

D O I：

10.1016/j.biochi.2008.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Pleiotrophin (PTN) is a polypeptide that belongs to a family of heparin-binding growth factor, which displays mitogenic activity for a wide variety of cells. Since PTN induces the proliferation of immune cells the mechanism of action was investigated. In the present study, we show for the first time that PTN induces the expression of inflammatory cytokines including TNF-alpha, IL-1 beta and IL-6 in quiescent human peripheral blood mononuclear cells (PBMC). These results emphasize the importance of PTN in the regulation of inflammatory processes. Elucidation of the mechanisms by which a host factor such PTN regulates cytokines production will significantly advance our understanding of endothelium-immunity interactions. (c) 2008 Published by Elsevier Masson SAS.

引用

页码：1791 / 1795

页数：5

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