Recyclable ionic liquid iodinating reagent for solvent free, regioselective iodination of activated aromatic and heteroaromatic amines

被引：18

作者：

Deshmukh, Amarsinh ^{[1
]}

Gore, Babasaheb ^{[1
]}

Thulasiram, Hirekodathakallu V. ^{[2
]}

Swamy, Vincent P. ^{[1
]}

机构：

[1] CSIR Natl Chem Lab, Organ Chem Div, Pune 411008, Maharashtra, India

[2] CSIR Natl Chem Lab, Chem Biol Unit, Pune 411008, Maharashtra, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 107期

关键词：

QUATERNARY AMMONIUM POLYHALIDES; BENZYLTRIMETHYLAMMONIUM DICHLOROIODATE; N-IODOSUCCINIMIDE; EFFICIENT METHOD; GREEN SOLVENTS; HALOGENATION; ARENES; MILD; PHENOLS; ACID;

D O I：

10.1039/c5ra14702f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article describes a simple, efficient method for iodination of activated aromatic and heteroaromatic amines using recyclable 1-butyl-3-methylpyridinium dichloroiodate (BMPDCI) as an ionic liquid iodinating reagent, in the absence of any solvent. The main advantages are a simple efficient procedure, good yields and no need for any base/toxic heavy metals, or oxidizing agents. The ionic liquid was recovered and recycled in five subsequent reactions, without much loss of activity. This method was applied for the synthesis of the antiprotozoal drug iodoquinol and the antifungal drug clioquinol.

引用

页码：88311 / 88315

页数：5

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