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Evolution of the linear DNA replicons of the Borrelia spirochetes

被引：68
作者：
Casjens, S [1 ]
机构：
[1] Univ Utah, Sch Med, Dept Oncol Sci, Div Med & Mol Genet, Logan, UT 84321 USA
来源：
CURRENT OPINION IN MICROBIOLOGY | 1999年 / 2卷 / 05期
关键词：
D O I：
10.1016/S1369-5274(99)00012-0
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Members of the spirochete genus Borrelia carry numerous linear DNA replicons with covalently closed hairpin telomeres. The genome of one member of this genus, B. burgdorferi B31, has now been completely characterized and contains a linear chromosome, twelve linear plasmids and nine circular extra-chromosomal elements. The phylogenetic position of the Borrelia spirochetes strongly suggests that a progenitor with circular replicons acquired the ability to replicate linear DNA molecules.
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页码：529 / 534
页数：6
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