Restoring ionotropic inhibition as an analgesic strategy

被引：23

作者：

Bonin, Robert P. ^{[1
]}

De Koninck, Yves ^{[1
,2
]}

机构：

[1] Inst Univ Sante Mentale Quebec, Ctr Rech, Unite Neurosci Cellulaires & Mol, Quebec City, PQ G1J 2G3, Canada

[2] Univ Laval, Dept Psychiat & Neurosci, Quebec City, PQ, Canada

来源：

NEUROSCIENCE LETTERS | 2013年 / 557卷

基金：

加拿大健康研究院;

关键词：

Dorsal horn; KCC2; Chloride; GABA; Glycine; Analgesia; LAMINA-I NEURONS; GABA(A) RECEPTOR SUBTYPES; SPINAL DORSAL-HORN; PROSTAGLANDIN E-2 PRODUCTION; GABAERGIC TONIC INHIBITION; PERIPHERAL-NERVE INJURY; GLYCINE RECEPTOR; INTRATHECAL STRYCHNINE; PATHOLOGICAL PAIN; SYNAPTIC-TRANSMISSION;

D O I：

10.1016/j.neulet.2013.09.047

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Neuronal inhibition in nociceptive relays of the spinal cord is essential for the proper processing of nociceptive information. In the spinal cord dorsal horn, the activity of synaptic and extrasynaptic GABA(A) and glycine receptors generates rapid, CI--dependent neuronal inhibition. A loss of this ionotropic inhibition, particularly through the collapse of the inhibitory CI--gradient, is a key mechanism by which pathological pain conditions develop. This review summarizes the roles of ionotropic inhibition in the regulation of nociception, and explores recent evidence that the potentiation of GABA(A) or glycine receptor activity or the enhancement of inhibitory drive can reverse pathological pain. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：43 / 51

页数：9

共 115 条

[1]

PGE2 selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons [J].