Latent reservoirs of HIV infection: Flushing with IL-2?

被引:10
作者
Cooper, DA [1 ]
Emery, S [1 ]
机构
[1] Univ New S Wales, Fac Med, Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW 2052, Australia
关键词
D O I
10.1038/9454
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new study suggests it may be possible to further dilute quantities of infectious HIV in infected people by combining potent anti-retroviral therapy with immune therapy using interleukin-2 (pages 651–655).
引用
收藏
页码:611 / 612
页数:2
相关论文
共 13 条
  • [1] [Anonymous], 1998, MMWR Recomm Rep, V47, P1
  • [2] Antiretroviral therapy for HIV infection in 1997 - Updated recommendations of the International AIDS Society USA panel
    Carpenter, CCJ
    Fischl, MA
    Hammer, SM
    Hirsch, MS
    Jacobsen, DM
    Katzenstein, DA
    Montaner, JSG
    Richman, DD
    Saag, MS
    Schooley, RT
    Thompson, MA
    Vella, S
    Yeni, PG
    Volberding, PA
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (24): : 1962 - 1969
  • [3] Outpatient continuous intravenous interleukin-2 or subcutaneous, polyethylene glycol-modified interleukin-2 in human immunodeficiency virus-infected patients: A randomized, controlled, multicenter study
    Carr, A
    Emery, S
    Lloyd, A
    Hoy, J
    Garsia, R
    French, M
    Stewart, G
    Fyfe, G
    Cooper, DA
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (04) : 992 - 999
  • [4] Quantification of latent tissue reservoirs and total body viral load in HIV-1 Infection
    Chun, TW
    Carruth, L
    Finzi, D
    Shen, XF
    DiGiuseppe, JA
    Taylor, H
    Hermankova, M
    Chadwick, K
    Margolick, J
    Quinn, TC
    Kuo, YH
    Brookmeyer, R
    Zeiger, MA
    BarditchCrovo, P
    Siliciano, RF
    [J]. NATURE, 1997, 387 (6629) : 183 - 188
  • [5] Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy
    Chun, TW
    Engel, D
    Mizell, SB
    Hallahan, CW
    Fischette, M
    Park, S
    Davey, RT
    Dybul, M
    Kovacs, JA
    Metcalf, JA
    Mican, JM
    Berrey, MM
    Corey, L
    Lane, HC
    Fauci, AS
    [J]. NATURE MEDICINE, 1999, 5 (06) : 651 - 655
  • [6] Therapeutic strategies for HIV infection - Time to think hard
    Cooper, DA
    Emery, S
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (18) : 1319 - 1321
  • [7] Davey RT, 1997, J INFECT DIS, V175, P781, DOI 10.1086/513971
  • [8] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION
    HO, DD
    NEUMANN, AU
    PERELSON, AS
    CHEN, W
    LEONARD, JM
    MARKOWITZ, M
    [J]. NATURE, 1995, 373 (6510) : 123 - 126
  • [9] Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus
    Kovacs, JA
    Vogel, S
    Albert, JM
    Falloon, J
    Davey, RT
    Walker, RE
    Polis, MA
    Spooner, K
    Metcalf, JA
    Baseler, M
    Fyfe, G
    Lane, HC
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (18) : 1350 - 1356
  • [10] HIV-1 replication in patients with undetectable plasma virus receiving HEART
    Natarajan, V
    Bosche, M
    Metcalf, JA
    Ward, DJ
    Lane, HC
    Kovacs, JA
    [J]. LANCET, 1999, 353 (9147) : 119 - 120