Interstitial fibrosis: tubular hypothesis versus glomerular hypothesis

被引：25

作者：

Christensen, Erik I. ^{[1
]}

Verroust, Pierre J. ^{[1
]}

机构：

[1] Aarhus Univ, Inst Anat, Dept Cell Biol, DK-8000 Aarhus C, Denmark

来源：

KIDNEY INTERNATIONAL | 2008年 / 74卷 / 10期

关键词：

D O I：

10.1038/ki.2008.421

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The pathogenesis of renal interstitial fibrosis leading eventually to renal failure is highly debatable. Whereas the so-called tubular hypothesis, involving an increased tubular uptake of potentially toxic substances that induce a variety of cytokines, growth factors, and profibrogenic factors, is based to a large extent on cell-culture studies, the glomerular hypothesis is based mainly on careful morphological observations. Unraveling the pathways appears to be extremely complex, but in vivo studies appear to offer the most reliable results.

引用

页码：1233 / 1236

页数：5

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