A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis

被引：147

作者：

Planque, Nathalie ^{[1
]}

Perbal, Bernard ^{[1
]}

机构：

[1] Univ Paris 7 D Diderot, Lab Oncol Virale & Mol, UFR Biochim, F-75005 Paris, France

来源：

CANCER CELL INTERNATIONAL | 2003年 / 3卷 / 1期

关键词：

Cancer; CCN1-6; CTGF; CYR61; Development; Differentiation; Growth control; NOVH; Tumourigenesis;

D O I：

10.1186/1475-2867-3-15

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The CCN (CYR61 [Cystein-rich61]/CTGF [connective tissue growth factor]/NOV [Nephroblastoma overexpressed]) proteins constitute a family of regulatory factors involved in many aspects of cell proliferation and differentiation. An increasing body of evidence indicates that abnormal expression of the CCN proteins is associated to tumourgenesis. The multimodular architecture of the CCN proteins, and the production of truncated isoforms in tumours, raise interesting questions regarding the participation of each individual module to the various biological properties of these proteins. In this article, we review the current data regarding the involvement of CCN proteins in tumourigenesis. We also attempt to provide structural basis for the stimulatory and inhibitory functions of the full length and truncated CCN proteins that are expressed in various tumour tissues.

引用

页数：15

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