A genomic regulatory network for development

被引：1104

作者：

Davidson, EH ^{[1
]}

Rast, JP

Oliveri, P

Ransick, A

Calestani, C

Yuh, CH

Minokawa, T

Amore, G

Hinman, V

Arenas-Mena, C

Otim, O

Brown, CT

Livi, CB

Lee, PY

Revilla, R

Rust, AG

Pan, ZJ

Schilstra, MJ

Clarke, PJC

Arnone, MI

Rowen, L

Cameron, RA

McClay, DR

Hood, L

Bolouri, H

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

[2] Univ Hertfordshire, Sci & Technol Res Ctr, Hatfield AL10 9AB, Herts, England

[3] Inst Syst Biol, Seattle, WA 98105 USA

[4] Duke Univ, Dept Zool, Durham, NC 27708 USA

[5] Staz Zool Anton Dohrn, I-80121 Naples, Italy

来源：

SCIENCE | 2002年 / 295卷 / 5560期

关键词：

D O I：

10.1126/science.1069883

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

引用

页码：1669 / 1678

页数：10

共 64 条

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