Genetic variability of hepatitis A virus

被引：102

作者：

Costa-Mattioli, M

Di Napoli, A

Ferré, V

Billaudel, S

Perez-Bercoff, R

Cristina, J

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[2] CNRS, Lab Virol Mol & Struct, F-91198 Gif Sur Yvette, France

[3] Ctr Hosp Univ Nantes, Inst Biol, UPRES EA1156, Virol Lab, F-44093 Nantes, France

[4] Univ Republica, Fac Ciencias, Ctr Invest Nucl, Dept Tecn Nucl Aplicadas, Montevideo 11400, Uruguay

来源：

JOURNAL OF GENERAL VIROLOGY | 2003年 / 84卷

关键词：

MOUTH-DISEASE VIRUS; RIO-DE-JANEIRO; RNA RECOMBINATION; MOLECULAR EPIDEMIOLOGY; SUBGENOTYPES IA; CELL-CULTURE; MONOCLONAL-ANTIBODIES; SHIFTING EPIDEMIOLOGY; NATURAL-POPULATIONS; NUCLEOTIDE-SEQUENCE;

D O I：

10.1099/vir.0.19532-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Knowledge of the molecular biology of hepatitis A virus (HAV) has increased exponentially since its identification. HAV exploits all known mechanisms of genetic variation to ensure survival, including mutation and genetic recombination. HAV has been characterized by the emergence of different genotypes, three human antigenic variants and only one major serotype. This paper reviews the genetic variability and molecular epidemiology of HAV. Its evolutionary mechanisms are described with particular emphasis on genetic recombination and HAV mutation rate. Genotypic classification methods are also discussed.

引用

页码：3191 / 3201

页数：11

共 126 条

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