Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma

被引：294

作者：

Dhule, Santosh S. ^{[1
,2
]}

Penfornis, Patrice ^{[1
]}

Frazier, Trivia ^{[1
]}

Walker, Ryan ^{[1
]}

Feldman, Joshua ^{[1
]}

Tan, Grace ^{[2
]}

He, Jibao ^{[3
]}

Alb, Alina ^{[4
]}

John, Vijay ^{[2
]}

Pochampally, Radhika ^{[1
,5
]}

机构：

[1] Tulane Univ, Hlth Sci Ctr, Tulane Ctr Stem Cell Res & Regenerat Med, New Orleans, LA 70112 USA

[2] Tulane Univ, Dept Chem & Biomol Engn, New Orleans, LA 70112 USA

[3] Tulane Univ, Coordinated Instrumentat Facil, New Orleans, LA 70112 USA

[4] Tulane Univ, Dept Phys & Engn Phys, New Orleans, LA 70112 USA

[5] Tulane Med Sch, Dept Pharmacol, New Orleans, LA USA

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2012年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Apoptosis; Autophagy; Curcumin; Cyclodextrin; Liposome; Osteosarcoma; IN-VITRO; CELL-DEATH; APOPTOSIS; SUPPRESSES; SOLUBILITY; AUTOPHAGY; GROWTH; CANCER; COMPLEXATION; CYTOTOXICITY;

D O I：

10.1016/j.nano.2011.07.011

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

The delivery of curcumin, a broad-spectrum anticancer drug, has been explored in the form of liposomal nanoparticles to treat osteosarcoma (OS). Curcumin is water insoluble and an effective delivery route is through encapsulation in cyclodextrins followed by a second encapsulation in liposomes. Liposomal curcumin's potential was evaluated against cancer models of mesenchymal (OS) and epithelial origin (breast cancer). The resulting 2-Hydroxypropyl-gamma-cyclodextrin/curcumin - liposome complex shows promising anticancer potential both in vitro and in vivo against KHOS OS cell line and MCF-7 breast cancer cell line. An interesting aspect is that liposomal curcumin initiates the caspase cascade that leads to apoptotic cell death in vitro in comparison with DMSO-curcumin induced autophagic cell death. In addition, the efficiency of the liposomal curcumin formulation was confirmed in vivo using a xenograft OS model. Curcumin-loaded gamma-cyclodextrin liposomes indicate significant potential as delivery vehicles for the treatment of cancers of different tissue origin. From the Clinical Editor: Curcumin-loaded gamma-cyclodextrin liposomes were demonstrated in vitro to have significant potential as delivery vehicles for the treatment of cancers of mesenchymal and epithelial origin. Differences between mechanisms of cell death were also evaluated. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：440 / 451

页数：12

共 49 条

[1]

Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of Akt and extracellular signal-regulated kinase signaling pathways [J].