Skin equivalents: clinical applications

被引：10

作者：

Braye, F ^{[1
]}

Hautier, A ^{[1
]}

Bouez, C ^{[1
]}

Damour, O ^{[1
]}

机构：

[1] Hop Edouard Herriot, Ctr Traitement Brules, F-69437 Lyon, France

来源：

PATHOLOGIE BIOLOGIE | 2005年 / 53卷 / 10期

关键词：

burns; skin substitutes; tissue engineering; wound healing;

D O I：

10.1016/j.patbio.2004.12.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The development of skin substitutes started 25 years ago with the cultivation of keratinocytes to replace the epidermis of extensively burned patients. It is now possible to reproduce in vitro the two layers of skin, epidermis and dermis. Cultured epidermises are now usually used in burn centers dealing with the more severe patients. They are provided by hospital or private laboratories. Dermal substrates are some collagen matrices, which act in vivo as a guide for the reconstruction of a neodermis. Living dermis include living fibroblasts. Different models are now available for clinical use. Living skin equivalent is obtained by coculturing fibroblast and keratinocytes on a collagen support. Clinical essays are going on for chronic wounds. We present the different skin equivalent models and their clinical applications. (c) 2005 Elsevier SAS. Tous droits reserves.

引用

页码：613 / 617

页数：5

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