A plant defense response effector induces microbial apoptosis

被引：147

作者：

Narasimhan, ML

Damsz, B

Coca, MA

Ibeas, JI

Yun, DJ

Pardo, JM

Hasegawa, PM

Bressan, RA ^{[1
]}

机构：

[1] Purdue Univ, Ctr Plant Environm Stress Physiol, W Lafayette, IN 47907 USA

[2] CSIC, Inst Recursos Nat & Agrobiol, E-41080 Seville, Spain

来源：

MOLECULAR CELL | 2001年 / 8卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1097-2765(01)00365-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Osmotin is a tobacco PR-5 protein that has antifungal activity and is implicated in host-plant defense. We show here that osmotin induces apoptosis in Saccharomyces cerevisiae. Induction of apoptosis was correlated with intracellular accumulation of reactive oxygen species and was mediated by RAS2, but not RAS1. Osmotin treatment resulted in suppression of transcription of stress-responsive genes via the RAS2/cAMP pathway. It was therefore concluded that osmotin induced proapoptotic signaling in yeast. The results indicate that the ability of antimicrobial proteins to induce microbial apoptosis could be an important factor in determining a pathogen's virulence and could therefore be targeted for the design of new antifungal drugs.

引用

页码：921 / 930

页数：10

共 55 条

[1] Inhibition of fungal and bacterial plant pathogens by synthetic peptides: in vitro growth inhibition, interaction between peptides and inhibition of disease progression [J].