Tumour-stroma interactions - Phenotypic and genetic alterations in mammary stroma: implications for tumour progression

被引:82
作者
Schor, SL [1 ]
Schor, AM [1 ]
机构
[1] Univ Dundee, Sch Dent, Unit Cell & Mol Biol, Dundee DD1 4HR, Scotland
关键词
cancer progression; cell motility; epithelial-stromal interactions; fibronectin;
D O I
10.1186/bcr325
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in the present review extend the repertoire of matrix signalling mechanisms, (1) introducing the concept of 'matrikines', these defined as proteinase-generated fragments of matrix macromolecules that display cryptic bioactivities not manifested by the native, full-length form of the molecule, and (2) indicating that a previously identified motogenic factor (migration stimulating factor [MSF]) produced by foetal and cancer patient fibroblasts is a genetically generated truncated isoform of fibronectin, which displays bioactivities cryptic in all previously identified fibronectin isoforms. These observations are discussed in the context of the contribution of a 'foetal-like' stroma to the progression of breast cancer.
引用
收藏
页码:373 / 379
页数:7
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