BacA-mediated bleomycin sensitivity in Sinorhizobium meliloti is independent of the unusual lipid A modification

被引：17

作者：

Ferguson, GP

Jansen, A

Marlow, VL

Walker, GC

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Univ Edinburgh, Sch Biol Sci, Inst Struct & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland

[3] Univ Edinburgh, Sch Biol Sci, Ctr Sci Extreme Condit, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 08期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1128/JB.188.8.3143-3148.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sinorhizobium meliloti bacA mutants are symbiotically defective, deoxycholate sensitive, and bleomycin resistant. We show that the bleomycin resistance phenotype is independent of the lipid A alteration and that the changes giving rise to both phenotypes are likely to be involved in the inability of bacA mutants to persist within their hosts.

引用

收藏

页码：3143 / 3148

页数：6

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