Intercalating nucleic acids: The influence of linker length and intercalator type on their duplex stabilities

被引：31

作者：

Christensen, UB

Wamberg, M

El-Essawy, FAG

Ismail, AEH

Nielsen, CB

Filichev, VV

Jessen, CH

Petersen, M

Pedersen, EB

机构：

[1] Univ So Denmark, Dept Chem, DK-5230 Odense M, Denmark

[2] Univ So Denmark, Nucleic Acid Ctr, Odense, Denmark

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2004年 / 23卷 / 1-2期

关键词：

intercalating nucleic acids; 7,9-dimethylpyrido[3 ',2 ': 4,5]thieno[3,2-d; pyrimidine-4(1H)-one; pyrene intercalators; DNA duplex stability of intercalating nucleic acids; oligonucleotides with covalently bound intercalators;

D O I：

10.1081/NCN-120027829

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new examples of intercalating nucleic acids were synthesized in order to evaluate the dependence of the length of the linker between oligo and intercalator on the thermal stability of their corresponding duplexes and triplexes.

引用

收藏

页码：207 / 225

页数：19

相关论文

共 23 条

[1] Insertion of 5-methyl-N-4-(1-pyrenylmethyl)cytidine into DNA. Duplex, three-way junction and triplex stabilities. [J].

AbdelRahman, AAH ;

Ali, OM ;

Pedersen, EB .

TETRAHEDRON, 1996, 52 (48) :15311-15324

[2] Intercalating nucleic acids with pyrene nucleotide analogues as next-nearest neighbors for excimer fluorescence detection of single-point mutations under nonstringent hybridization conditions [J].

Christensen, UB ;

Pedersen, EB .

HELVETICA CHIMICA ACTA, 2003, 86 (06) :2090-2097

[3] Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol:: stabilisation of dsDNA and discrimination of DNA over RNA [J].

Christensen, UB ;

Pedersen, EB .

NUCLEIC ACIDS RESEARCH, 2002, 30 (22) :4918-4925

[4] 3-AMINO-FURO[2,3-B]PYRIDINES [J].

GEWALD, K ;

JANSCH, HJ .

JOURNAL FUR PRAKTISCHE CHEMIE, 1976, 318 (02) :313-320

[5] OLIGODEOXYNUCLEOTIDE-DIRECTED PHOTOINDUCED CROSS-LINKING OF HIV PROVIRAL DNA VIA TRIPLE-HELIX FORMATION [J].

GIOVANNANGELI, C ;

THUONG, NT ;

HELENE, C .

NUCLEIC ACIDS RESEARCH, 1992, 20 (16) :4275-4281

[6] SYNTHESIS AND REACTIONS OF SOME THIENOPYRIDINE DERIVATIVES [J].

HASSAN, KM ;

ELDEAN, AMK ;

YOUSSEF, MSK ;

ATTA, FM ;

ABBADY, MS .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1990, 47 (1-2) :181-189

[7] STRUCTURE AND SYNTHESIS OF DIHYDROXYPENTYLURACIL FROM BACTERIOPHAGE SP-15 DEOXYRIBONUCLEIC-ACID [J].

HAYASHI, H ;

NAKANISHI, K ;

BRANDON, C ;

MARMUR, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (26) :8749-8757

[8] A comparison of the solution structures of an LNA:DNA duplex and the unmodified DNA:DNA duplex [J].

Jensen, GA ;

Singh, SK ;

Kumar, R ;

Wengel, J ;

Jacobsen, JP .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 2001, (07) :1224-1232

[9] Triple helices formed at oligopyrimidine•oligopurine sequences with base pair inversions:: effect of a triplex-specific ligand on stability and selectivity [J].

Kukreti, S ;

Sun, JS ;

Loakes, D ;

Brown, DM ;

Nguyen, CH ;

Bisagni, E ;

Garestier, T ;

Helene, C .

NUCLEIC ACIDS RESEARCH, 1998, 26 (09) :2179-2183

[10] STRUCTURAL CONSIDERATIONS IN INTERACTION OF DNA AND ACRIDINES [J].

LERMAN, LS .

JOURNAL OF MOLECULAR BIOLOGY, 1961, 3 (01) :18-&