One-hybrid screens at the Saccharomyces cerevisiae HMR locus identify novel transcriptional silencing factors

被引:16
作者
Andrulis, ED
Zappulla, DC
Alexieva-Botcheva, K
Evangelista, C
Sternglanz, R [1 ]
机构
[1] SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA
[2] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
关键词
D O I
10.1534/genetics.166.1.631
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In Saccharonyces cerevisiae, genes located at the telomeres mid the HM loci are subject to transcriptional silencing, Here, we report results of screening a Gal4 DNA-binding domain hybrid library for proteins that cause silencing, when targeted to a silencer-defective HMR locus.
引用
收藏
页码:631 / 635
页数:5
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