Serum level of oxidative stress marker is dramatically low in patients with rheumatoid arthritis treated with tocilizumab

被引：45

作者：

Hirao, Makoto ^{[2
]}

Yamasaki, Naomi ^{[2
]}

Oze, Hiroki ^{[2
]}

Ebina, Kosuke ^{[2
]}

Nampei, Akihide ^{[2
]}

Kawato, Yoshitaka ^{[2
]}

Shi, Kenrin ^{[2
]}

Yoshikawa, Hideki ^{[2
]}

Nishimoto, Norihiro ^{[3
]}

Hashimoto, Jun ^{[1
,2
]}

机构：

[1] Natl Hosp Org, Dept Immune Dis Ctr, Osaka Minami Med Ctr, Kawachinagano City, Osaka 5868521, Japan

[2] Osaka Univ, Grad Sch Med, Dept Orthopaed, Osaka, Japan

[3] Wakayama Sch Med, Lab Immune Regulat, Wakayama, Japan

来源：

RHEUMATOLOGY INTERNATIONAL | 2012年 / 32卷 / 12期

关键词：

Rheumatoid arthritis; Oxidative stress; Reactive oxygen species; IL-6; Tocilizumab; INTIMA-MEDIA THICKNESS; AORTIC STIFFNESS; DISEASE; ATHEROSCLEROSIS; GENERATION; REDUCTION; PREDICTOR; RADICALS; EVENTS; ARTERY;

D O I：

10.1007/s00296-011-2135-0

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Regarding the pathobiology of rheumatoid arthritis, oxidative stress induced by reactive oxygen species is an important mechanism that underlies destructive and proliferative synovitis. Abundant amounts of reactive oxygen species have been detected in the synovial fluid of inflamed rheumatoid joints. It is reported that drugs that block tumor necrosis factor-alpha reduce the oxidative stress marker levels in patients with rheumatoid arthritis. In this study, we measured reactive oxygen species using a free radical analytical system in patients with rheumatoid arthritis treated with disease-modifying antirheumatic drugs, tumor necrosis factor-alpha-blocking drugs (infliximab, etanercept), and an interleukin-6-blocking drug (tocilizumab). The serum level of oxidative stress was drastically low in patients with rheumatoid arthritis treated with tocilizumab, suggesting that interleukin-6 blocking therapy reduces not only joint damage, but also vascular degeneration in patients with rheumatoid arthritis. We believe that such a drastic effect would reduce the incidence of cardiovascular events and mortality in patients with rheumatoid arthritis.

引用

页码：4041 / 4045

页数：5

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