Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways

被引：44

作者：

Gao, Jian-Li ^{[1
]}

Shi, Jun-Min ^{[1
]}

He, Kai ^{[2
]}

Zhang, Qing-Wen ^{[1
]}

Li, Shao-Ping ^{[1
]}

Lee, Simon Ming-Yuen ^{[1
]}

Wang, Yi-Tao ^{[1
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, Taipa 999078, Macao, Peoples R China

[2] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China

来源：

ONCOLOGY REPORTS | 2008年 / 20卷 / 04期

关键词：

breast cancer; Corydalis yanhusuo; cell invasion; mitogen-activated protein kinase; metalloproteinases;

D O I：

10.3892/or_00000079

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Yanhusuo (Corydalis yanhusuo W.T. Wang) is a well-known traditional Chinese medicine (TCM). In this study, we attempted to characterize in detail the signaling cascades that produce its anti-metastatic effect on the human breast cancer cell line, MDA-MB-231. We found that the yanhusuo extract inhibited the migration and invasion of MDA-MB-231 cells in vitro. In addition, the yanhusuo extract inhibited the mRNA expression and activity of metalloproteinase-9 (MMP-9). The anti-cancer metastasis effect of yanhusuo involved the activation of p38 and inhibition of ERK1/2 and SAPK/JNK mitogen-activated protein kinase (MAPK) signaling. Our experiments identified the biological activity of yanhusuo against cancer metastasis in vitro and provide a rationale for its further investigation.

引用

页码：819 / 824

页数：6

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