Synthesis of ML-3000, an inhibitor of cyclooxygenase and 5-lipoxygenase

[1] Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures [J]. JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (11) : 3849 - 3862

[2] BELOTTI D, 1997, IN PRESS SYNLETT

[3] Cyclization of delta,epsilon-acetylenic amines and aminoacids into cyclic enamines. A very efficient and simple access to polysubstituted pyrrolidines. [J]. TETRAHEDRON LETTERS, 1997, 38 (15) : 2677 - 2680

[4] COSSY J, 1996, Patent No. 9612760

[5] DIETL HK, 1973, TETRAHEDRON LETT, P1273

[6] SELECTIVE DEOXYGENATION OF KETONES AND ALDEHYDES INCLUDING HINDERED SYSTEMS WITH SODIUM CYANOBOROHYDRIDE [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (11) : 3662 - 3668

[7] (6,7-DIARYLDIHYDROPYRROLIZIN-5-YL)ACETIC ACIDS, A NOVEL CLASS OF POTENT DUAL INHIBITORS OF BOTH CYCLOOXYGENASE AND 5-LIPOXYGENASE [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (12) : 1894 - 1897

[8] PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ORGANOBORON COMPOUNDS [J]. CHEMICAL REVIEWS, 1995, 95 (07) : 2457 - 2483

[9] Rabasseda X., 1995, Drugs of the Future, V20, P1007

[10] RITTER K, 1993, SYNTHESIS-STUTTGART, P735

[1] Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures [J]. JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (11) : 3849 - 3862

[2] BELOTTI D, 1997, IN PRESS SYNLETT

[3] Cyclization of delta,epsilon-acetylenic amines and aminoacids into cyclic enamines. A very efficient and simple access to polysubstituted pyrrolidines. [J]. TETRAHEDRON LETTERS, 1997, 38 (15) : 2677 - 2680

[4] COSSY J, 1996, Patent No. 9612760

[5] DIETL HK, 1973, TETRAHEDRON LETT, P1273

[6] SELECTIVE DEOXYGENATION OF KETONES AND ALDEHYDES INCLUDING HINDERED SYSTEMS WITH SODIUM CYANOBOROHYDRIDE [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (11) : 3662 - 3668

[7] (6,7-DIARYLDIHYDROPYRROLIZIN-5-YL)ACETIC ACIDS, A NOVEL CLASS OF POTENT DUAL INHIBITORS OF BOTH CYCLOOXYGENASE AND 5-LIPOXYGENASE [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (12) : 1894 - 1897

[8] PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ORGANOBORON COMPOUNDS [J]. CHEMICAL REVIEWS, 1995, 95 (07) : 2457 - 2483

[9] Rabasseda X., 1995, Drugs of the Future, V20, P1007

[10] RITTER K, 1993, SYNTHESIS-STUTTGART, P735