Efficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods

被引：28

作者：

Bowman, MD ^{[1
]}

Jacobson, MM ^{[1
]}

Pujanauski, BG ^{[1
]}

Blackwell, HE ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

TETRAHEDRON | 2006年 / 62卷 / 19期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.tet.2006.02.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a method for the efficient construction of small molecule macroarrays using microwave-assisted SPOT-synthesis. Macroarrays of 1,3-diphenylpropenones (chalcones) were synthesized rapidly and in high purity starting from robust, Wang-linker-derivatized planar supports. We have optimized the entire chalcone macroarray construction process and evaluated the efficiency and utility of microwave-assisted reactions in array synthesis. Microwave heating was found to be most beneficial for reactions that require temperatures greater than the boiling points of the solvents. These microwave-assisted conditions permitted straightforward access to macroarrays of 2,4,6-triarylpyridines derived from the original chalcone scaffold. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4715 / 4727

页数：13

共 45 条

[1] Reproducibility across microwave instruments:: Preparation of a set of 24 compounds on a multiwell plate under temperature-controlled conditions [J].