Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives:: Effect of alkyl chain length

被引：101

作者：

Mori, Shuichi ^{[1
]}

Miyake, Shinya ^{[1
]}

Kobe, Takayoshi ^{[1
]}

Nakaya, Takaaki ^{[2
]}

Fuller, Stephen D. ^{[3
]}

Kato, Nobuo ^{[1
]}

Kaihatsu, Kunihiro ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Osaka 5670047, Japan

[2] Osaka Univ, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Div Struct Biol, Oxford OX3 7BN, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 14期

关键词：

epigallocatechin gallate; influenza virus; lipase-catalyzed esterification; antivirus agent;

D O I：

10.1016/j.bmcl.2008.02.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of fatty acid monoester derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4249 / 4252

页数：4

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