Perinatal Programming of Asthma: The Role of Gut Microbiota

被引:70
作者
Azad, Meghan B. [1 ]
Kozyrskyj, Anita L. [1 ]
机构
[1] Univ Alberta, Dept Pediat, Edmonton Clin, Hlth Acad, Edmonton, AB T6G 1C9, Canada
来源
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年
关键词
EARLY-LIFE EXPOSURE; INTESTINAL MICROBIOTA; DEVELOPMENTAL ORIGINS; ALLERGIC DISEASES; CHILDHOOD ASTHMA; AIRWAY INFLAMMATION; ANTIBIOTIC USE; BRONCHIAL HYPERRESPONSIVENESS; CYTOKINE RESPONSES; FECAL MICROBIOTA;
D O I
10.1155/2012/932072
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism. In this paper, we present evidence for the perinatal programming of asthma via the intestinal microbiome. While epigenetic mechanisms continue to provide new explanations for the programming hypothesis of asthma development, it is increasingly apparent that the intestinal microbiota plays an independent and potentially interactive role. Commensal gut bacteria are essential to immune system development, and exposures disrupting the infant gut microbiota have been linked to asthma. This paper summarizes the recent findings that implicate caesarean delivery, breastfeeding, perinatal stress, probiotics, and antibiotics as modifiers of infant gut microbiota in the development of asthma.
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页数:9
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