Influence of sex hormone disturbances on the internal structure of the mandible in newborn mice

被引：21

作者：

Fujita, T ^{[1
]}

Ohtani, J ^{[1
]}

Shigekawa, M ^{[1
]}

Kawata, T ^{[1
]}

Kaku, M ^{[1
]}

Kohno, S ^{[1
]}

Motokawa, M ^{[1
]}

Tohma, Y ^{[1
]}

Tanne, K ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed Sci, Dept Orthodont & Craniofacial Dev Biol, Minami Ku, Hiroshima 7348553, Japan

来源：

EUROPEAN JOURNAL OF ORTHODONTICS | 2006年 / 28卷 / 02期

关键词：

D O I：

10.1093/ejo/cji093

中图分类号：

R78 [口腔科学];

学科分类号：

1003 [口腔医学];

摘要：

It has not yet been clarified how sex hormones affect craniofacial bone development immediately after birth. The purpose of this study was to examine the effects of sex hormone deficiency on craniofacial bone development immediately after birth, in terms of the internal structure of the mandible in newborn mice with orchiectomy (ORX) and ovariectomy (OVX). ORX, OVX and a sham-operation were performed on 40 five-day-old C57BL/6J mice. Eight weeks after surgery, each mandible was subjected to histomorphometric analysis of trabecular (Tr) and cortical (Ct) bone mineral density (BMD) by peripheral quantitative computed tomography (pQCT). In the experimental groups, a significant reduction in BMD was found in comparison with the control groups. In histomorphometric analysis, the number of tartrate-resistant acid phosphatase (TRAP)-positive cells in the condyle and the thickness of the condylar cartilage layer was significantly greater in the experimental mice than in the controls. Trabecular bone volume of the condyle measured on azocarmine-aniline blue (AZAN) sections was significantly less in the experimental mice than in the controls. These results indicate that mandibular growth is inhibited by sex hormone disturbances and the relevant internal structures changed. The findings show that sex hormones are one of the key determinants of mandibular growth and development immediately after birth.

引用

页码：190 / 194

页数：5

共 18 条

[1]

THE ROLE OF THE CONDYLAR CARTILAGE IN MANDIBULAR GROWTH - A STUDY IN THANATOPHORIC DYSPLASIA [J].