Cyclo-oxygenase-2 (COX-2) inhibition reduces apoptosis in acute myocardial infarction

被引:24
作者
Abbate, A.
Limana, F.
Capogrossi, M. C.
Santini, D.
Biondi-Zoccai, G. G. L.
Scarpa, S.
Germani, A.
Straino, S.
Severino, A.
Vasaturo, F.
Campioni, M.
Liuzzo, G.
Crea, F.
Vetrovec, G. W.
Biasucci, L. M.
Baldi, A.
机构
[1] Virginia Commonwealth Univ, Dept Med, Richmond, VA 23233 USA
[2] Catholic Univ, Inst Cardiol, Rome, Italy
[3] Ist Dermopatico Immacolata, Dept Vasc Pathol, Rome, Italy
[4] Campus Bio Med Univ, Sect Oncol, Rome, Italy
[5] Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy
[6] Ctr Cardiol Fdz Monzino, Milan, Italy
[7] Univ Naples 2, Sect Pathol Anat, Dept Biochem & Biophys F Cedrangolo, Naples, Italy
关键词
apoptosis; COX2-inhibitors; cyclo-oxygenase; myocardial infarction; remodelling;
D O I
10.1007/s10495-006-6306-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:1061 / 1063
页数:3
相关论文
共 8 条
[1]   Infarct-related artery occlusion, tissue markers of ischaemia, and increased apoptosis in the peri-infarct viable myocardium [J].
Abbate, A ;
Bussani, R ;
Biondi-Zoccai, GGL ;
Santini, D ;
Petrolini, A ;
De Giorgio, F ;
Vasaturo, F ;
Scarpa, S ;
Severino, A ;
Liuzzo, G ;
Leone, AM ;
Baldi, F ;
Sinagra, G ;
Silvestri, F ;
Vetrovec, GW ;
Crea, F ;
Biasucci, LM ;
Baldi, A .
EUROPEAN HEART JOURNAL, 2005, 26 (19) :2039-2045
[2]   Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe? [J].
Abbate, A ;
Santini, D ;
Biondi-Zoccai, GGL ;
Scarpa, S ;
Vasaturo, F ;
Liuzzo, G ;
Bussani, R ;
Silvestri, F ;
Baldi, F ;
Crea, F ;
Biasucci, LM ;
Baldi, A .
HEART, 2004, 90 (04) :440-443
[3]   Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction [J].
Chandrashekhar, Y ;
Sen, S ;
Anway, R ;
Shuros, A ;
Arland, I .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (02) :295-301
[4]   Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse [J].
LaPointe, MC ;
Mendez, M ;
Leung, A ;
Tao, ZY ;
Yang, XP .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 286 (04) :H1416-H1424
[5]  
LIMANA F, 2005, CIRC RES
[6]   Inhibition of COX pathway in experimental myocardial infarction [J].
Saito, T ;
Rodger, IW ;
Hu, F ;
Robinson, R ;
Huynh, T ;
Giaid, A .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004, 37 (01) :71-77
[7]   Inducible nitric oxide synthase modulates cyclooxygenase-2 activity in the heart of conscious rabbits during the late phase of ischemic preconditioning [J].
Shinmura, K ;
Xuan, YT ;
Tang, XL ;
Kodani, E ;
Han, H ;
Zhu, YQ ;
Bolli, R .
CIRCULATION RESEARCH, 2002, 90 (05) :602-608
[8]   Cardiovascular hazard and non-steroidal anti-inflammatory drugs [J].
Wong, DR ;
Wang, MA ;
Cheng, Y ;
FitzGerald, GA .
CURRENT OPINION IN PHARMACOLOGY, 2005, 5 (02) :204-210