TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells

被引：98

作者：

Qian, Yigang ^{[1
]}

Deng, Junfang ^{[1
]}

Geng, Lei ^{[1
]}

Xie, Haiyang ^{[1
]}

Jiang, Guoping ^{[1
]}

Zhou, Lin ^{[1
]}

Wang, Yan ^{[1
]}

Yin, Shenyong ^{[1
]}

Feng, Xiaowen ^{[1
]}

Liu, Junwei ^{[1
]}

Ye, Zhou ^{[1
]}

Zheng, Shusen ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med,Affiliated Hosp 1, Dept Hepatobiliary Pancreat Surg,Minist Publ Hlth, Key Lab Organ Transplantat Zhejiang Prov,Key Lab, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 08期

关键词：

TLR4; B7-H1; MAPK; bladder cancer;

D O I：

10.1080/07357900801941852

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

TLR4 (Toll-like receptor 4) and B7-H1, which were known to be restricted to immune cells in the past, were found to be aberrantly expressed in a majority of tumor cells, facilitating tumor evasion from immune surveillance. Our study demonstrated that activation of TLR4 signaling in bladder cancer cells up-regulated B7-H1 expression. Furthermore, this regulation was significantly attenuated by ERK or JNK inhibitor. Our results elucidated the molecule mechanism of regulation of B7-H1 expression through TLR4 signaling and may suggest new strategies of down-regulating the cancer-associated B7-H1 expression for bladder cancer treatment.

引用

页码：816 / 821

页数：6

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