Antigen-presentation properties of plasmacytoid dendritic cells

被引：403

作者：

Villadangos, Jose A. ^{[1
]}

Young, Louise ^{[1
,2
]}

机构：

[1] Univ Melbourne, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

来源：

IMMUNITY | 2008年 / 29卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.immuni.2008.09.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One of the remaining enigmas of the dendritic cell (DC) network is the potential contribution of plasmacytoid DCs (pDCs) to antigen presentation. Although the antigen-presentation capacity of conventional DCs (cDCs) is clearly defined, pDCs are generally attributed as having little, if any, antigen-presentation function. Instead, pDCs are regarded as immunomodulating cells, capable of directing the immune response through their secretion of large amounts of type I interferons. In this review, we examine the evidence for a potential role of pDC in antigen capture, processing, and presentation to T cells at sites of infection and in the lymph nodes.

引用

页码：352 / 361

页数：10

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